San Francisco 49ers WR Brandon Aiyuk (ankle) suffered a high-ankle sprain in Week 16 against the Arizona Cardinals and will not play in Week 17 versus the Seattle Seahawks.

Footballguys View: Aiyuk had a fine rookie season for the 49ers and we appreciate his upside for the future. He finishes his first pro season with 60 catches for 748 yards and five receiving touchdowns. Entering the 2021 season, Aiyuk should perform like a WR2/flex play for Fantasy GMs.