Pittsburgh Steelers QB Ben Roethlisberger (knee), TE Matt Spaeth (hand) and LB Ryan Shazier (shoulder) are out for Week 4. Shazier returned to practice in limited fashion Wednesday, Sept. 30.

New York Giants WR Victor Cruz (calf, knee) felt his calf injury in individual drills in practice Wednesday, Sept. 30, according to head coach Tom Coughlin.

Philadelphia Eagles LB Mychal Kendricks (hamstring) could return in Week 4 against the Washington Redskins. He practiced Tuesday, Sept. 29, and was on the field Wednesday, Sept. 30.

Indianapolis Colts QB Andrew Luck (shoulder) is likely to play in Week 4, according to head coach Chuck Pagano. Luck was limited in practice Wednesday, Sept. 30.

Kansas City Chiefs CB Phillip Gaines (knee) is out for the season with a torn anterior cruciate ligament, according to head coach Andy Reid.

Updating an earlier report, Philadelphia Eagles LB Kiko Alonso (knee) had arthroscopic surgery earlier this week on his left knee and is likely to return in a few weeks.

Seattle Seahawks RB Marshawn Lynch (hamstring) is 50-50 to play in Week 4, according to a source.

Jacksonville Jaguars TE Julius Thomas (hand) is unlikely to play in Week 4, but he said he hopes to be cleared soon. Thomas has been doing individual work with a splint on his hand, but he hasn’t caught passes yet. He was checked out by a doctor earlier this week. ‘The good news is, no bad news,’ Thomas said. ‘But no dates (to return), no nothing. Just waiting to get cleared.’

Buffalo Bills RB Karlos Williams currently leads the NFL with an average of 7.75 yards per carry.

Buffalo Bills WR Sammy Watkins (calf) may not be able to play in Week 4 against the New York Giants, according to head coach Rex Ryan. Watkins is not practicing Wednesday, Sept. 30. ‘Part of when he had the surgery, it takes away a little bit of your conditioning,’ Ryan said. ‘He has the pull in camp, misses time. Now he’s coming back and he’s got something else. It’s just one of those things.’