Indianapolis Colts QB Andrew Luck will face the Jacksonville Jaguars in Week 4. Last season he completed 52 of his 71 pass attempts for 623 yards, five touchdowns and no interceptions against the Jaguars, although he was sacked seven times.

Indianapolis Colts WR Andre Johnson will face the Jacksonville Jaguars in Week 4. As a member of the Houston Texans last season Johnson had his only double-digit reception and 100-yard game against the Jaguars. He finished with 10 grabs for 134 yards and a touchdown Dec. 28, 2014, against the Jags, and he has three 100-yard games against them in his past six, including a career-high 273 yards in a game Nov. 18, 2012.

Indianapolis Colts WR T.Y. Hilton will meet the Jacksonville Jaguars in Week 4. In his past three meetings with the Jags he has 20 reception for 357 yards and a touchdown, while also running once for 15 yards.

Dallas Cowboys DE Randy Gregory (ankle) is hoping to return to the field after the team’s Week 6 bye.

Updating a previous report, Buffalo Bills WR Sammy Watkins (calf) probably will not be able to play in the Week 4 game against New York Giants, according to head coach Rex Ryan.

San Francisco 49ers LB NaVorro Bowman (non-injury) did not participate in practice Wednesday, Sept. 30. CB Kenneth Acker (back), OG Alex Boone (shoulder), LB Ahmad Brooks (shoulder), WR Bruce Ellington (ankle), S L.J. McCray (hip) and TE Vance McDonald (knee) fully participated in practice.

San Francisco 49ers RB Reggie Bush (calf) fully participated in practice Wednesday, Sept. 30.

San Francisco 49ers TE Vernon Davis (knee) did not participate in practice Wednesday, Sept. 30.

New York Jets OG Willie Colon (knee), TE Jeff Cumberland (concussion), S Jaiquawn Jarrett (knee), WR Chris Owusu (knee), LB Trevor Reilly (finger) and CB Darrin Walls (hamstring) did not practice Wednesday, Sept. 30. LB Quinton Coples (elbow), CB Antonio Cromartie (hip) and CB Darrelle Revis (hamstring) were limited. DT T.J. Barnes (ankle), DE Stephen Bowen (knee), OG James Carpenter (back), LB David Harris (finger) and WR Devin Smith (ribs) participated fully.

Indianapolis Colts WR Andre Johnson has only seven receptions on 18 targets for 51 yards in three games and has been a complete non-factor. ‘A lot of people don’t realize how hard that is, to try to build being your first time in a new place,’ Johnson said. ‘It takes a lot of work. It takes time for a guy to feel very comfortable, to make that relationship very comfortable. It’s something we work on every day. Other than that, I’m just here working and trying to get better as a player daily.’ QB Andrew Luck and Johnson didn’t spend much time together during the preseason, and three of Luck’s league-high seven interceptions have come on passes thrown to Johnson.